Skip to content
Back to Resources

Machine Learning Models Accurately Interpret Liver Histology and Are Associated With Disease Progression in Patients With Primary Sclerosing Cholangitis

♦ Primary sclerosing cholangitis (PSC) is a chronic fibrosing cholangiopathy
marked by heterogeneous clinical presentation

♦ Fibrosis progression is the primary histologic endpoint in two Phase 3 clinical trials of PSC (ClinicalTrials.gov NCT03872921 and NCT03890120)

♦ Current histologic staging systems for PSC, including the Nakanuma
classification, are predictive of clinical events, but have only fair interobserver agreement and may require specialized staining procedures

♦ Variability in histologic evaluation in patients with PSC may hinder disease
staging and confound clinical trial results Travis et al.
Get In Touch

Get In Touch

PathAI Media

Company Contact

Liz Storti

Chief People Officer

elizabeth.storti@pathai.com

Media Contact

Daniel Donato

LifeSci Communications

ddonato@lifescicomms.com

516-474-0554