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Liver Explore

Enhancing the discovery of novel biomarkers in MASH and other liver diseases with quantitative, cellular-level characterization of tissue and fibrosis microarchitecture in liver biopsies.

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Liver Explore1 is an AI-powered panel of >1,000 quantitative human interpretable features (HIFs) that spatially characterize liver tissue biopsy microarchitecture from H&E whole slide images.

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Tissue and cell classification

Automated detection and AI heatmaps visualizing >20 tissue regions and >10 cell types

H&E fibrosis detection & Subtyping Icon

H&E fibrosis detection & subtyping

AI-powered identification of collagen/fibrosis tissue - directly on H&E image without additional slide scanning

HIF Panel Icon

HIF Panel

>1,000 curated HIFs for rapid, scalable, and standardized quantification of the entire tissue

Human Interpretable Features (HIFs) are metrics that capture areas, counts, densities, and proximities of cell types within each tissue region to enable spatial analyses

Fibrosis Subtyping

  • Portal fibrosis
  • Periportal fibrosis
  • Perivenular fibrosis
  • Perisinusoidal fibrosis
  • Incomplete septal fibrosis
  • Complete septal fibrosis
  • Nodular fibrosis
NASH fibrosis cells

Landmarks

  • Portal tract
  • Central vein
  • Zone 1
  • Zone 2
  • Zone 3
NASH Landmark cells

Cell Type & Tissue Region Classification

  • Immune cells
  • Normal hepatocytes
  • Ballooned hepatocytes
  • Steatotic hepatocytes
  • Bile ducts
  • Blood vessels
  • Portal inflammation
  • Interface hepatitis
  • Lobular inflammation
liver explore cell type and tissue image

Product Profile

  • Indications: Metabolic dysfunction-associated steatohepatitis
  • Intended Use: Research Use Only
  • Stain Type: H&E
  • Scanners: Leica Aperio® AT2
  • Outputs: Panel (.csv) for >1,000 quantitative Human Interpretable Features (HIFs); Heatmap classification of tissue, cells, fibrosis subtypes and liver landmarks.
Liver Explore1 may be compatible with other liver indications and scanners. Please contact us for more information.

Unlocking novel insights for the future of MASH drug development

Improve

Quantification of established histologic biomarkers of MASH (e.g., patterns of fibrosis, counts of ballooned hepatocytes)

Identify

Novel histological biomarkers and drivers of therapeutic efficacy

Generate

Comprehensive supporting evidence for regulatory submission

Resources

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Connect with our business development team to learn more about Liver Explore.
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1Liver Explore is for research use only. Not for use in diagnostic procedures.