Liver Explore

Enhancing the discovery of novel biomarkers in MASH and other liver diseases with quantitative, cellular-level characterization of tissue and fibrosis microarchitecture in liver biopsies.

Liver Explore¹ is an AI-powered panel of >1,000 quantitative human interpretable features (HIFs) that spatially characterize liver tissue biopsy microarchitecture from H&E whole slide images.

Tissue and cell classification

Automated detection and AI heatmaps visualizing >20 tissue regions and >10 cell types

H&E fibrosis detection & subtyping

AI-powered identification of collagen/fibrosis tissue - directly on H&E image without additional slide scanning

HIF Panel

>1,000 curated HIFs for rapid, scalable, and standardized quantification of the entire tissue

Human Interpretable Features (HIFs) are metrics that capture areas, counts, densities, and proximities of cell types within each tissue region to enable spatial analyses

Fibrosis Subtyping

Portal fibrosis
Periportal fibrosis
Perivenular fibrosis
Perisinusoidal fibrosis
Incomplete septal fibrosis
Complete septal fibrosis
Nodular fibrosis

Landmarks

Portal tract
Central vein
Zone 1
Zone 2
Zone 3

Cell Type & Tissue Region Classification

Immune cells
Normal hepatocytes
Ballooned hepatocytes
Steatotic hepatocytes
Bile ducts
Blood vessels
Portal inflammation
Interface hepatitis
Lobular inflammation

liver explore cell type and tissue image

Product Profile

Indications: Metabolic dysfunction-associated steatohepatitis
Intended Use: Research Use Only
Stain Type: H&E
Scanners: Leica Aperio^® AT2
Outputs: Panel (.csv) for >1,000 quantitative Human Interpretable Features (HIFs); Heatmap classification of tissue, cells, fibrosis subtypes and liver landmarks.

Liver Explore¹ may be compatible with other liver indications and scanners. Please contact us for more information.

Unlocking novel insights for the future of MASH drug development

Improve

Quantification of established histologic biomarkers of MASH (e.g., patterns of fibrosis, counts of ballooned hepatocytes)

Identify

Novel histological biomarkers and drivers of therapeutic efficacy

Generate

Comprehensive supporting evidence for regulatory submission

Resources

Contact Us

Connect with our business development team to learn more about Liver Explore.

¹Liver Explore is for research use only. Not for use in diagnostic procedures.