Analyzing patient endotypes to characterize heterogeneity in real-world data for inflammatory bowel disease

Ulcerative colitis (UC) and Crohn’s disease (CD) are heterogeneous diseases and patients exhibit variable responses to available treatments.

Identifying robust disease endotypes could improve patient stratification and inform therapeutic decisions.

In a previous study, we advanced IBD endotype hypotheses derived from clinical studies that demonstrate distinct molecular signatures in both UC and CD.

While clinical trial data are limited, large real-world datasets offer valuable insights into disease biology and treatment response.

This study leverages multi-modal data from the SPARC IBD cohort (Crohn’s & Colitis Foundation IBD Plexus program) to classify patient endotypes and link them to clinical, molecular and histological features.