♦ The hepatic venous pressure gradient (HVPG) reliably measures portal pressure, including the presence of clinically significant portal hypertension (CSPH; HVPG ≥10 mm Hg)
♦ CSPH is associated with an increased risk of hepatic decompensation and mortality
♦ Measurement and interpretation of HVPG require expertise, with up to 30% of HVPG readings deemed inaccurate
♦ We previously utilized a machine learning (ML) research platform (PathAI, Inc., Boston, MA) to quantify fibrosis and other histologic features of nonalcoholic steatohepatitis (NASH), and characterize the heterogeneity of fibrosis in patients with cirrhosis Bosch et al.
♦ CSPH is associated with an increased risk of hepatic decompensation and mortality
♦ Measurement and interpretation of HVPG require expertise, with up to 30% of HVPG readings deemed inaccurate
♦ We previously utilized a machine learning (ML) research platform (PathAI, Inc., Boston, MA) to quantify fibrosis and other histologic features of nonalcoholic steatohepatitis (NASH), and characterize the heterogeneity of fibrosis in patients with cirrhosis Bosch et al.
