---
title: The utility of AI-powered spatial classification of intratumoral CD8+ immune-cell topology in predicting overall survival in patients with melanoma as part of the CheckMate 067 clinical trial
description: The utility of AI-powered spatial classification of intratumoral CD8+ immune-cell topology in predicting overall survival in patients with melanoma as part of the CheckMate 067 clinical trial
---

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# [The utility of AI-powered spatial classification of intratumoral CD8+ immune-cell topology in predicting overall survival in patients with melanoma as part of the CheckMate 067 clinical trial](https://www.pathai.com/resources/the-utility-of-ai-powered-spatial-classification-of-intratumoral-cd8-immune-cell-topology-in-predicting-overall-survival-in-patients-with-melanoma-as-part-of-)

 Written by [Admin](https://www.pathai.com/resources/author/admin) | Nov 10, 2021 5:00:00 AM

## Study Background

 Using an artificial intelligence (AI)-driven algorithm, we retrospectively assessed the value of intratumoral CD8 topology together with PD-L1 expression as a composite biomarker of response to immunotherapy in patients with advanced melanoma in the phase 3 CheckMate 067 clinical trial (NCT01844505) Lee et al.

[View Poster](https://www.pathai.com/hubfs/2025%20Assets/Lee_SITC2021_Poster_CD8_Topology_Final_draft_19OCT21.pdf)

[View full post](https://www.pathai.com/resources/the-utility-of-ai-powered-spatial-classification-of-intratumoral-cd8-immune-cell-topology-in-predicting-overall-survival-in-patients-with-melanoma-as-part-of-)

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