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Retrospective AI-based Measurement of NASH Histology (AIM-NASH) Analysis of Biopsies From Phase 2 Study of Resmetirom Confirms Significant Treatment-induced Changes in Histologic Features of Nonalcoholic Steatohepatitis

EASL 2022

Study Background

In the current retrospective analysis, we demonstrate the utility of an AI-based tool (AIM-NASH) for scoring NASH histology of liver biopsies from a Phase 2 trial of resmetirom (MGL-3196), a liver-targeted, oral, once-daily selective thyroid hormone receptor-β agonist in development for treatment of NASH with significant fibrosis.


Harrison SA, et al. Lancet. 2019;394(10213):2012-2024.
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Harrison et al.