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Machine Learning Models Accurately Interpret Liver Histology and Are Associated With Disease Progression in Patients With Primary Sclerosing Cholangitis

EASL 2020

Study Background

♦ Primary sclerosing cholangitis (PSC) is a chronic fibrosing cholangiopathy
marked by heterogeneous clinical presentation

♦ Fibrosis progression is the primary histologic endpoint in two Phase 3 clinical trials of PSC ( NCT03872921 and NCT03890120)

♦ Current histologic staging systems for PSC, including the Nakanuma
classification, are predictive of clinical events, but have only fair interobserver agreement and may require specialized staining procedures

♦ Variability in histologic evaluation in patients with PSC may hinder disease
staging and confound clinical trial results
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Travis et al.