---
title: Comparison of the effects of semaglutide on liver histology in patients with non-alcoholic steatohepatitis cirrhosis between machine learning model assessment and pathologist evaluation
description: Comparison of the effects of semaglutide on liver histology in patients with non-alcoholic steatohepatitis cirrhosis between machine learning model assessment and pathologist evaluation
---

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# [Comparison of the effects of semaglutide on liver histology in patients with non-alcoholic steatohepatitis cirrhosis between machine learning model assessment and pathologist evaluation](https://www.pathai.com/resources/comparison-of-the-effects-of-semaglutide-on-liver-histology-in-patients-with-non-alcoholic-steatohepatitis-cirrhosis-between-machine-learning-model-assessment)

 Written by [Admin](https://www.pathai.com/resources/author/admin) | Nov 8, 2022 5:00:00 AM

## Study Background

- Liver biopsies evaluated by hepatopathologists are a key method for assessing treatment response in trials of non-alcoholic steatohepatitis (NASH).1,2  
    - Artificial intelligence has also shown promise in liver biopsy assessment.2
- Identification and assessment of NASH components can be subject to inter- and intra-observer variability, especially for hepatocyte ballooning.3
- This post hoc analysis aimed to assess the effect of semaglutide vs placebo on histological components of NASH as assessed by a pathologist and PathAI’s machine learning (ML) models. 
    - The analysis used data from a randomized, double-blind, placebo-controlled phase 2 trial investigating once-weekly subcutaneous semaglutide 2.4 mg in patients with NASH and compensated cirrhosis.

 References:

1. NAFLD Research Center, University of California San Diego, La Jolla, CA, USA;
2. Novo Nordisk A/S, Søborg, Denmark;
3. PathAI, Inc., Boston, MA, USA;

Loomba et al.

[View Poster](https://www.pathai.com/hubfs/2025%20Assets/FINAL_Loomba_AASLD_PathAI-key-results_poster_Approval-Draft_26Oct22.pdf)

[View full post](https://www.pathai.com/resources/comparison-of-the-effects-of-semaglutide-on-liver-histology-in-patients-with-non-alcoholic-steatohepatitis-cirrhosis-between-machine-learning-model-assessment)

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