Characteristics of the tumor microenvironment in IDH1-mutated cholangiocarcinoma patients from ClarIDHy trial

Using machine learning models to quantify histologic features of the CCA pre-treatment tissue sections, we aimed to identify correlates of tumor microenvironment associated with:

• IDH1 mutation status
• Early disease progression (patients experienced progression or death within 1.54 months)
• Plasma 2-HG levels (median, 630 ng/ml)