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Characteristics of the tumor microenvironment in IDH1-mutated cholangiocarcinoma patients from ClarIDHy trial

SITC 2022

Study Background

Using machine learning models to quantify histologic features of the CCA pre-treatment tissue sections, we aimed to identify correlates of tumor microenvironment associated with:

  • IDH1 mutation status

  • Early disease progression (patients experienced progression or death within 1.54 months)

  • Plasma 2-HG levels (median, 630 ng/ml)

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Saatcioglu et al.