---
title: Accurate quantification of slide-level HER2 scores in breast cancer using a machine-learning model, AIM-HER2 Breast Cancer
description: Accurate quantification of slide-level HER2 scores in breast cancer using a machine-learning model, AIM-HER2 Breast Cancer
---

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# [Accurate quantification of slide-level HER2 scores in breast cancer using a machine-learning model, AIM-HER2 Breast Cancer](https://www.pathai.com/resources/accurate-quantification-of-slide-level-her2-scores-in-breast-cancer-using-a-machine-learning-modelaim-her2-breast-cancer)

 Written by [Admin](https://www.pathai.com/resources/author/admin) | Dec 5, 2023 5:00:00 AM

## Study Background

 HER2 expression level is a key factor in determining the optimal treatment course for breast cancer patients. Roughly 15% of breast cancers are HER2+, and determination of HER2 status is routinely assessed by immunohistochemistry (IHC). Accurate assessment of the HER2 IHC score (0, 1+, 2+, 3+) by pathologists is therefore critical, especially in light of novel therapeutic approaches demonstrating efficacy in the HER2-low setting (IHC scores 1+, and 2+/FISH-) 1,2.

To assist pathologists with the consistent provision of reproducible and accurate scores across the entire HER2 scoring range, we developed a machine-learning algorithm (“AIM-HER2”) to generate accurate, slide-level HER2 scores aligned with ASCO-CAP guidelines in clinical breast cancer HER2 IHC specimens. Zahil Shanis 1, Ryan Cabeen 1, #, Shreya Chakraborty 1,#, John Shamshoian 1, Marc Thibault 1, Blake Martin 1, Harshith Pagidela 1, Dinkar Juyal 1, Syed Ashar Javed 1, William Qian 1,#, Juhyun Kim 1, Beckett Rucker 1, Jacqueline Brosnan-Cashman 1, Harsha Pokkalla 1, Jimish Mehta 1,#, Amaro Taylor-Weiner 1,#, Ben Glass 1, Santhosh Balasubramanian 1

*1 PathAI, Boston, MA  
# Employed at PathAI at time of study*

[View Poster](https://www.pathai.com/hubfs/2025%20Assets/AIM-HER2-SABCS-Poster_FINAL.pdf)

[View full post](https://www.pathai.com/resources/accurate-quantification-of-slide-level-her2-scores-in-breast-cancer-using-a-machine-learning-modelaim-her2-breast-cancer)

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