---
title: Discoiding Domain Receptor 1 (DDR1) expression is associated with degree of immune exclusion across epithelial tumors
description: Discoiding Domain Receptor 1 (DDR1) expression is associated with degree of immune exclusion across epithelial tumors
---

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# [Discoiding Domain Receptor 1 (DDR1) expression is associated with degree of immune exclusion across epithelial tumors](https://www.pathai.com/publications/discoiding-domain-receptor-1-ddr1-expression-is-associated-with-degree-of-immune-exclusion-across-epithelial-tumors)

 Written by [Admin](https://www.pathai.com/publications/author/admin) | Apr 5, 2024 4:00:00 AM

## Background

- Discoidin domain receptor 1 (DDR1) is highly expressed in epithelial cancers and has been implicated in tumor growth, invasion, and lack of response to therapy.
- DDR1 contributes to immune exclusion by promoting tumor collagen alignment in in vivo models. However, it remains unclear how DDR1 expression affects immune cell infiltration in human tumors.
- A first-in-human trial of PRTH-101, a DDR1-targeted therapeutic antibody, is underway.
- Establishing a correlation between DDR1 expression and immune infiltration in the tumor microenvironment (TME) will help clarify DDR1’s role in the TME and inform indication and patient selection strategies for DDR1-targeted therapies.

## Conference

AACR 2024

[View Poster](https://www.incendiatx.com/file.cfm/49/docs/poster_aacr2024_cd8fromhe_ml_final.pdf)

[View full post](https://www.pathai.com/publications/discoiding-domain-receptor-1-ddr1-expression-is-associated-with-degree-of-immune-exclusion-across-epithelial-tumors)

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