---
title: "Comparative analysis and cross-validation of Artificial Intelligence digital pathology vs. expert hepatopathologist scoring in MASLD biopsies : Results of the LITMUS Study Cohort"
description: "Comparative analysis and cross-validation of Artificial Intelligence digital pathology (PathAI AIM-MASH and HistoIndex qFIBS ) vs. expert hepatopathologist
scoring in MASLD biopsies : Results of the LITMUS Study Cohort"
---

[PathAI Publications ](https://www.pathai.com/publications)

# [Comparative analysis and cross-validation of Artificial Intelligence digital pathology vs. expert hepatopathologist scoring in MASLD biopsies : Results of the LITMUS Study Cohort](https://www.pathai.com/publications/comparative-analysis-and-cross-validation-of-artificial-intelligence-digital-pathology-vs.-expert-hepatopathologist-scoring-in-masld-biopsies-result-1755644445533)

 Written by [Admin](https://www.pathai.com/publications/author/admin) | May 7, 2025 4:00:00 AM

## Study Background

Reasonably-likely surrogate endpoints for drug development in pre-cirrhotic Metabolic-dysfunction Associated Steatohepatitis (MASH) are histologically defined, requiring accurate measurements at trial entry and completion.

Histopathologist scoring (MASLD Activity Score (MAS) and fibrosis stage (F)) can both exhibit inter- and  
intra -observer variation.

AI models (PathAI AIM-MASH and HistoIndex qFIB) may assist in improving scoring consistency.

Aim: Independently assess the performance of these AI tools compared to expert histopathologists in liver  
biopsy samples from across Europe.

 

Conference

EASL (European Association for the Study of the Liver) Congress 2025 

[View Poster](https://drive.google.com/file/d/1gbgtqSg7vNvIxWF9JGhPQxXnujFLbXZt/view)

[View full post](https://www.pathai.com/publications/comparative-analysis-and-cross-validation-of-artificial-intelligence-digital-pathology-vs.-expert-hepatopathologist-scoring-in-masld-biopsies-result-1755644445533)

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