---
title: Analyzing patient endotypes to characterize heterogeneity in real-world data for inflammatory bowel disease
description: Analyzing patient endotypes to characterize heterogeneity in real-world data for inflammatory bowel disease
---

[PathAI Publications ](https://www.pathai.com/publications)

# [Analyzing patient endotypes to characterize heterogeneity in real-world data for inflammatory bowel disease](https://www.pathai.com/publications/analyzing-patient-endotypes-to-characterize-heterogeneity-in-real-world-data-for-inflammatory-bowel-disease)

 Written by [Admin](https://www.pathai.com/publications/author/admin) | May 3, 2025 4:00:00 AM

## Introduction

 

- Ulcerative colitis (UC) and Crohn’s disease (CD) are heterogeneous diseases and patients exhibit variable responses to available treatments.
- Identifying robust disease endotypes could improve patient stratification and inform therapeutic decisions.
- In a previous study, we advanced IBD endotype hypotheses derived from clinical studies that demonstrate distinct molecular signatures in both UC and CD.
- While clinical trial data are limited, large real-world datasets offer valuable insights into disease biology and treatment response.
- This study leverages multi-modal data from the SPARC IBD cohort (Crohn’s & Colitis Foundation IBD Plexus program) to classify patient endotypes and link them to clinical, molecular and histological features.

## Conference

DDW 2025

[View Poster](https://drive.google.com/file/d/1wbQZXRWIEktQXne4zXlott8MVWLyjJ1l/view)

[View full post](https://www.pathai.com/publications/analyzing-patient-endotypes-to-characterize-heterogeneity-in-real-world-data-for-inflammatory-bowel-disease)

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