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Introducing PathExplore™ IOP

Empowering cancer drug developers and clinical researchers with AI-powered insights.1

PathExplore IOP: Immuno-Oncology Profiling


PathExplore IOP (Immuno-Oncology Profiling) offers unparalleled visual and quantitative characterization of patterns of lymphocyte infiltration within the tumor and stroma. This innovation allows classification of immune phenotype based on diagnostic H&E images, facilitating deeper insights into immune response characteristics.

Enhance Immune-Oncology Profiling workflows with spatial characterization of tumor-infiltrating lymphocytes (TILs) in the tumor microenvironment (TME) directly from H&E.

PathExplore IOP features

Identify, quantify, and classify TILs and immune phenotypes with high spatial resolution

  • Visualize the density and spatial distribution of TILs with single-cell resolution
  • Identify High and Low TIL density regions within tissue regions
  • Analyze TIL populations and distributions by tissue compartments
  • Quantify cell-cell interactions between tumor and immune cells
  • Curated features designed to characterize the tumor-immune microenvironment

Distinct immune profiles (IP) stratifies patient prognosis and treatment response

  • Measure % of “High TIL” and “Low TIL” micro patches in each tissue area enables accurate classification of immune phenotypes taking into account heterogeneity of distribution
  • Quantitative analytics is used to identify generalizable thresholds for assigning slide-level-based IPs
  • Investigations indicate promising applications of IP for patient stratification and novel biomarker discovery

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PathExplore IOP is for research use only. Not for use in diagnostic procedures.