NASH Explore
Advancing precision medicine for NASH with quantitative, cellular-level characterization of NASH tissue and fibrosis microarchitecture

NASH Explore™ is an AI-powered panel of >500 quantitative human interpretable features (HIFs) that spatially characterize NASH tissue biopsy microarchitecture from H&E whole slide images.1

Tissue and cell classification
Automated detection and AI heatmaps visualizing >20 tissue regions and >10 cell types

H&E fibrosis detection & subtyping
AI-powered identification of collagen/fibrosis tissue - directly on H&E image without additional slide scanning

HIF Panel
>500 curated HIFs for rapid, scalable, and standardized quantification of the entire tissue
Human Interpretable Features (HIFs) are metrics that capture areas, counts, densities, and proximities of cell types within each tissue region to enable spatial analyses
Fibrosis Subtyping
- Portal fibrosis
- Periportal fibrosis
- Perivenular fibrosis
- Perisinusoidal fibrosis
- Incomplete septal fibrosis
- Complete septal fibrosis
- Nodular fibrosis

Landmarks
- Portal tract
- Central vein
- Zone 1
- Zone 2
- Zone 3

Cell Type & Tissue Region Classification
- Immune cells
- Normal hepatocytes
- Ballooned hepatocytes
- Steatotic hepatocytes
- Bile ducts
- Blood vessels
- Portal inflammation
- Interface hepatitis
- Lobular inflammation

Product Profile
- Indications: Nonalcoholic steatohepatitis
- Intended Use: Research Use Only
- Stain Type: H&E
- Scanners: Leica Aperio® AT2
- Outputs: Panel (.csv) for >500 quantitative Human Interpretable Features (HIFs); Heatmap classification of tissue, cells, fibrosis subtypes and liver landmarks.

Unlocking novel insights for the future of NASH drug development

Improve
Quantification of established histologic biomarkers of NASH (e.g., patterns of fibrosis, counts of ballooned hepatocytes)

Identify
Novel histological biomarkers and drivers of therapeutic efficacy

Generate
Comprehensive supporting evidence for regulatory submission
Resources

1NASH Explore is research use only. Not for use in diagnostic procedures.