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Immunohistochemistry (IHC) · Gastroenterology
Villin is a 95 kDa calcium-regulated, actin-binding protein that plays a role iin regulating actin filament assembly. It is a major constituent in the microvilli, which compose the brush border of epithelial cells forming absorptive surfaces of the intestinal and renal proximal tubular epithelia. In normal human tissue, villin is expressed by a limited number of simple epithelia of the gastrointestinal and urogenital tract. Among neoplasms, villin is predominantly expressed in tumors of colorectal origin. Antibodies to villin are useful in identifying malignant cells from primary and metastatic colorectal carcinomas.