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Immunohistochemistry (IHC) · Urology
The biomarker telomerase has been shown to be upregulated in human epithelial cancers, and in bladder cancers. A key component of telomerase is a protein called human telomerase reverse transcriptase (hTERT), which can be recognised in cytological specimens by Anti-hTERT Antibody (SCD-A7) using immunocytochemistry (ICC). Specifically, the presence of hTERT in urothelial cells shed from the bladder wall into urine, can be detected in this way. A positive test for hTERT in urothelial cells indicates an altered process of some kind, and since 90% of bladder cancers upregulate telomerase, it indicates an increased chance that cancer is present.