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Immunohistochemistry (IHC) · All
Synaptophysin is a 38 kDa membrane glycoprotein expressed in neuroendocrine cells and neurons involved in transmission via synaptic vehicles. Despite its abundance, the function of synaptophysin remains largely unknown, however an effect on efficient endocytosis of synaptic vesicles has recently been reported.Synaptophysin is a useful marker for identification of neuroendocrine neoplasm, such as neuroendocrine lung tumors (e.g. carcinoid, atypic carcinoid, SCLC, LCNEC and non-small cell lung cancer), neuroendocrine tumors of the gastroenteropancreatic tract, e.g. neuroendocrine tumors (NETs), neuroendocrine carcinoma (NECs) and other epithelial neuroendocrine neoplasms such as pituitary adenomas, medullary thyroid carcinoma and parathyroid adenomas. The new clone DAK-SYNAP is raised against a recombinant immunogen corresponding to the C-terminal cytoplasmic domain of human synaptophysin.