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Immunohistochemistry (IHC) · Urology
This test uses a combination of several antibodies (applied to a single slide) that differentially stain for basal cells and neoplastic cells in the prostate: P504S stains prostate adenocarcinoma, whereas p63 and the high molecular weight cytokeratins stain benign prostate basal epithelial tissue. These are combined with C-MYC, a proto-oncogene. C-MYC is amplified in 20-30% of breast cancer cases; associated with HER2 amplification and poor outcome. C-MYC expression in primary prostate tumor is biologically relevant and may be a predictor of future biochemical recurrence. This combination may help differentiate prostate cancer from precancerous lesions such as prostatic intraepithelial neoplasia (PIN), especially when tissue is limited.