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MUM1

Immunohistochemistry (IHC) · Oncology
Labels MUM1 protein in a subset of light zone germinal centre (GC) B cells (probably centrocytes and their progeny), plasma cells and activated T cells. It also labels and a wide spectrum of hematolymphoid neoplasms derived from these cells. Of non-hematolymphoid neoplasms only a proportion of melanomas are labeled (1, 2). Antibodies to MUM1 protein are useful for identifying the transition of GC B cells (BCL6+) to immunoblasts and plasma cells (CD138+), for the study of the histogenesis of B-cell lymphomas, and for the subclassification of these malignancies.