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Immunohistochemistry (IHC) · Dermatology, Gastroenterology
The antibody labels the transmembrane tyrosine kinase receptor CD117/c-kit, located in hematopoietic stem cells, melanocytes, mast cells, Cajal cells, germ cells, basal cells of skin, and mammary ductal epithelia. Antibodies to CD117 may be useful for the identification of several cancers expressing c-kit, including mast cell diseases, acute myeloid leukemia (AML), small cell lung carcinoma (SCLC), and Ewing’s sarcoma, and in the differentiation between gastrointestinal stromal tumors (GISTs) and other intra-abdominal mesenchymal tumors.