PathAI logo

CAM 5.2

Immunohistochemistry (IHC) · All
Cytokeratins are polypeptide chains that form structural proteins within the epithelial cell cytoskeleton. Nineteen different molecular forms of cytokeratin have been identified in both normal and malignant epithelial cell lines.1 Because specific combinations of cytokeratin peptides are associated with different epithelial cells, these peptides are clinically important markers for classifying carcinomas (tumors of epithelial origin)2 and for distinguishing carcinomas from malignant tumors of nonepithelial origin such as lymphomas, melanomas, and sarcomas. The identification of cytokeratin has gained increasing importance in immunopathology. A scheme for the use of anti-cytokeratin in the classification of tumors is presented in the current Manual of Clinical Laboratory Immunology, Chapter 145.5.3