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AIM-HI Ulcerative Colitis

AI-measurement of histologic indices for ulcerative colitis

Histological remission is emerging as an important biomarker for therapeutic efficacy and predicting patient clinical relapse


Histologic measurement has demonstrated stronger association with relapse-free survival vs. endoscopic mucosal healing1. Additionally, histology can identify patients with increased risk of symptom relapse, hospitalization, steroid utilization, and/or surgical intervention over the course of years2.


AI-measurement of histologic index for ulcerative colitis (AIM-HI UC)* is the only AI-powered Geboes scoring tool that assists pathologists in accurately and reproducibly measuring histological stage and improvement for ulcerative colitis research and clinical trials.

*AIM-HI UC is For Research Use Only. Not for use in diagnostic procedures.


De-risk therapy development

Histology compliments traditional measures of disease activity and can help complete understanding of drug outcomes

Simplify complex workflows

Bridge multiple scoring systems (Geboes subgrades, Robarts Histopathological Index, and Nancy Histological Index) instantaneously to adapt to evolving UC regulatory guidance

Standardize testing

AI-powered histology provides reproducible, reliable assessments for both research and clinical trials

Specifications

  • Indication: Ulcerative Colitis
  • Intended Use: Research Use Only; for use as secondary and/or exploratory endpoint in clinical trials to identify histologic remission (GS<2) and histologic
    improvement (GS≤3.1).
  • Assay: H&E sigmoid or rectum biopsies
  • Scanner: Leica Aperio T2 and GT450
  • Outputs: Geboes Grade Level Score; Geboes subgrades, calculated Robarts Histopathological Index, converted Nancy Histological Index
  • Histoendoscopic Mucosal Improvement (HEMI) Detection (GS < 3.1)

Automated and reproducible scoring across all indices


AIM-HI UC outputs include Geboes Grade Level Score, all Geboes subgrades, calculated Robarts Histopathological Index, converted Nancy Histological Index, and Histoendoscopic Mucosal Improvement (HEMI) Detection.

Resources

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*AIM-HI UC is For Research Use Only. Not for use in diagnostic procedures.
1Christensen, B. et al. 2017. Clin Gastroenterol Hepatol.
2 Ozaki et al. 2018; Christensen et al. 2017; Cushing et al. 2020